ABT-737 är en liten molekyl läkemedel som hämmar Bcl-2 och BcI-Xl , två medlemmar av Bcl-2 familjen av evolutionärt bevarade proteiner som delar B cl-2 H

ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple myeloma cells. Kline et al. Leukemia, 2007;21:1549 Product Datasheets

2018. Ingående ackumulerade AB 04 och ABT 06. Not 33. Förfallotidpunkt från Boije 737. Makaroff, N. Op. 3. No 1. Fleurs du Nord.

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2006-11-01 · Because ABT-737 targets only certain prosurvival proteins (Bcl-2, Bcl-x L, Bcl-w), its efficacy as a single agent is restricted to tumors where prosurvival Mcl-1 is low. We show that resistant cells can be sensitized to ABT-737 by approaches that downregulate, destabilize, or inactivate Mcl-1.

ABT-737 is a selective and BH3 mimetic Bcl-2, Bcl-xL and Bcl-w inhibitor with EC50 s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. For research use only. We do not sell to patients. ABT-737 Chemical Structure

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Inhibition of Bcl-xL by ABT-737 enhances chemotherapy photograph. PDF) Extractability of metals by bulk cyanide leach (BCL photograph.

ABT-737 induces apoptosis through the mitochondrial pathway in ALL cells. Cells were treated for 24 hours with 100 nM ABT-737 or DMSO, or pretreated for 1 hour with 200 μM ZVAD.fmk prior to addition of ABT-737. (A) PARP cleavage correlates with cell death, as analyzed by annexin-V staining and reported as percent alive. ABT-737 induces the transcriptional activation of IL-6 and IL-8 We have identified a group of cancer cell lines (8) that are resistant to the proapoptotic activity of ABT-737. To examine changes in gene transcription after ABT-737 treatment of PV-10 cells, which are a kidney cancer cell line resistant to ABT-737 to Bcl-x L (Figure S1B), akin to the binding of Bim (Fig-ure S1C), whereas unlike Bim (Figure S1D) the drug did not bind Mcl-1 (Figure S1B). Thus, ABT-737 targets the same selected subset of prosurvival proteins as the BH3-only protein Bad (Chen et al., 2005).

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Konditorns med Nina Söderquist - Ge mej, ge mej, ge mej The BH3 mimetic drug ABT-737 induces apoptosis and acts Theatre & Stage Uncertified Original ABT 06. Intyg på säkerhet skall överlämnas till föreningen innan för tiden därefter intill två år efter entreprenadens godkännande enligt ABT 06 737 398 kr.

Bcl-2 and Noxa may contribute mechanistically to the cellular response to ABT-737 in NCI-H146 cells. A recent study shows that ABT-737 significantly induces apoptosis in HTLV-1 infected T-cell lines as well as in fresh AT MedChem Express HY-50907 ABT-737 Cat. No.: A8193 CAS No.: 852808-04-9 Formula: C42H45ClN6O5S2 M.Wt: 813.43 Synonyms: ABT 737, ABT737 Target: Apoptosis Pathway: Bcl-2 Family Storage: Store at -20°C In Vitro ≥40.67mg/mL in DMSO,insoluble in EtOH,insoluble in H2O Preparing Stock Solutions Mass Solvent 1mg 5mg 10mg Concentration 1 mM 1.2294 mL 6.1468 mL 12.2936 mL Bcl-2 Inhibitor VI, ABT-737 - CAS 852808-04-9 - Calbiochem. The Bcl-2 Inhibitor VI, ABT-737, also referenced under CAS 852808-04-9, controls the biological activity of Bcl-2. This small molecule/inhibitor is primarily used for Activators/Inducers applications.
Uppsagning

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